Pryethrum
(Chrysanthemum cineraria folium) is a perennial temperate plant with small white, daisy-like flowers from which natural insecticides, the pyrethrins, are derived. Traditionally, pyrethrum was produced in many African countries where hand-labor was used to plant, harvest, and dry the crop. Political upheaval, drought, and lack of an organized development and marketing structure resulted in unreliable pyrethrum supplies for U.S. manufacturers. In the late 1980's, however, Australia began a pyrethrum development project and is now a major producer of the crop. This has helped to stabilize the industry. Kenya, Tanzania, Rwanda and Ecuador still remain the primary suppliers of pyrethrum, however. Smaller amounts are grown in Japan, Brazil and India.

The United States is the principal consumer of world supplies of pyrethrum. Demand for pyrethrum-based insecticides is on the rise because of its long safety record, very low toxicity, and rapid breakdown. Because of the selective and relatively small-scale use of pyrethrum for over 160 years, there has been relatively little development of insect resistance. As a result of these characteristics, in recent years the use of pyrethrum based products has increased dramatically on organic farms and for home insect control.
Pyrethrins are contact poisons which quickly act upon the nervous system. In small doses, insects are knocked down; the toxins excite the neurons causing convulsions. In the final stages of poisoning, the insect cannot coordinate its voluntary muscles (ataxia); the nervous system appears 'exhausted'. But insects can recover unless the dosage is sufficient to kill.
For pyrethrum to be fully lethal to insects, it is generally combined with a 'synergist', a chemical that enhances the pyrethrins action on the nervous system. The synergist may be as simple as vegetable oil or diatomaceous earth, or more complex like piperonyl butoxide.
Pyrethrins have low toxicity to mammals, because mammals can metabolize the chemicals. Pyrethrins breakdown in the presence of sunlight, moisture, or oxygen making the chemicals biodegradable. In the past two centuries of pyrethrum use, very few insects have developed resistance to these toxins.